Lung cancer is the leading cause of cancer-related mortality worldwide. Low-dose CT (LDCT) lung cancer screening (LCS) reduces lung cancer-specific mortality by 20%, yet participation remains low, often below 15%, compared with 60–75% for other cancer screening programmes.

Barriers

Barriers such as limited accessibility, stigma, fear of diagnosis, and misconceptions contribute to poor uptake, particularly among high-risk groups, including heavy smokers, ethnic minorities, and individuals from lower socioeconomic backgrounds. Various recruitment strategies—such as personalised invitations, media campaigns, and primary care referrals—have been implemented, but their effectiveness across different populations remains unclear.

This umbrella review will synthesise evidence from systematic reviews to identify the most effective recruitment strategies for improving LCS participation.

Read the full paper:
https://hrbopenresearch.org/articles/8-71/v1

Cervical cancer remains one of the leading causes of cancer-related death among women globally, despite the availability of highly effective tools for prevention. Human papillomavirus (HPV) vaccination and HPV-based screening have demonstrated strong efficacy in reducing cervical cancer incidence and mortality. Nevertheless, their uptake and implementation remain uneven across regions, with the highest burden of disease persisting in low- and middle-income countries (LMICs).

A recent review published in ASCO Educational Book explores the challenges and opportunities associated with global cervical cancer elimination, offering insights that extend well beyond a single disease. The paper examines the evidence base for HPV vaccination and HPV-based screening, while critically assessing the health system, policy, and implementation barriers that limit their impact.

The review hlights how innovations developed for cervical cancer prevention—such as digital health platforms, mobile and community-based screening, and task-shifting—can serve as a model for strengthening primary and secondary prevention strategies for other cancers. Achieving the WHO’s 90–70–90 targets for cervical cancer elimination will require sustained policy commitment, health system strengthening, and international collaboration, but it also presents a unique opportunity to transform cancer prevention more broadly.

Read the full paper:
https://ascopubs.org/doi/10.1200/EDBK-25-473702